Welcome to Inferrence

What is Inferrence?

Inferrence is a protein analysis platform that discovers cryptic binding sites — drug targets that only appear when a protein shifts into transient conformational states. Traditional structure prediction tools like AlphaFold produce a single static snapshot, missing these hidden pockets entirely.

Inferrence generates dozens of plausible 3D conformations from an amino acid sequence, then analyzes each one for druggable binding sites. Sites that appear in some conformations but not others are flagged as cryptic — potential targets for novel therapeutics.

Conformational Diversity

Generate multiple structural states from a single sequence, capturing the dynamic nature of proteins in solution.

Cryptic Site Discovery

Identify binding pockets that only exist in transient states — invisible to static structure methods.

Druggability Analysis

Score each detected pocket for drug-likeness based on volume, hydrophobicity, and geometric properties.

Simple API

Submit a sequence and get results. No structural biology expertise required to get started.

How It Works

1. Submit an amino acid sequence through the web interface or API
2. Generate diverse conformational states using a masked language model trained on protein structures
3. Detect binding pockets in each conformation using computational geometry (fpocket)
4. Compare pockets across states to identify cryptic sites that appear only transiently
5. Explore results in an interactive 3D viewer with druggability scores

Read the Science section for a deeper look at the pipeline, or jump to the Quick Start to try it yourself.